Transfection is a powerful analytical tool enabling studies of gene products and functions in
eukaryotic cells. Successful delivery of genetic material into cells depends on DNA quantity …

Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases,
due to the lack of early diagnosis, and high relapse rate after conventional therapies …

The success of gene therapy relies on gene nanocarriers to achieve therapeutic effects in
vivo. Surface shielding of poly (ethylene glycol)(PEG), known as PEGylation, onto gene …

Dynamic materials, which include ionic polymeric materials, contain specific bonds or
interactions that can reversibly break and reform under certain stimuli or conditions. Among …

As the cleaners of cells, lysosomes play an important role in circulating organic matter within
cells, recovering damaged organelles, and removing waste via endocytosis. Because …

Gene therapy has attracted much attention because of its unique mechanism of action, non-
toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues …

Cationic polymers dynamically complex DNA into complexes (polyplexes). So, upon dilution,
polyplexes easily dissociate and lose transfection ability, limiting their in vivo systemic gene …

Tanshinone IIA (TS-IIA) and salvianic acid A (SAA) are the main pharmacological active
constituents of Danshen, which exhibit potent effects on atherosclerosis. A combination of …

A new era of medical technology in cancer treatment is a directly specific modification of
gene expression in tumor cells by nucleic acid delivery. Currently, the main challenge to …