Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Brown fat is emerging as an interesting and promising target for therapeutic intervention in
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …

Low levels of physical activity and the presence of obesity are associated with mitochondrial
dysfunction. In addition, mitochondrial dysfunction has been associated with the …

Obesity and diabetes has become a major epidemic across the globe. Controlling obesity
has been a challenge since this would require either increased physical activity or reduced …

The development of sustained, long-term endothermy was one of the major transitions in the
evolution of vertebrates. Thermogenesis in endotherms does not only occur via shivering or …

New appetite‐regulating antiobesity treatments such as semaglutide and agents under
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …

Purpose Sarcopenia, the loss of muscle mass combined with the loss of muscle function,
has become a public health issue. There is an urgent need for interventions. The study …

Thermogenesis is an important homeostatic mechanism essential for survival and normal
physiological functions in mammals. Both brown adipose tissue (BAT)(ie uncoupling protein …