Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and
energy metabolism. Glycolysis in non-oxygen condition is the main energy production …

Head and neck squamous cell carcinoma (HNSCC) is a molecularly heterogeneous
disease, with a 5-year survival rate that still hovers at~ 60% despite recent advancements …

Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk
for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its …

Mitochondria are the only organelles regulated by two genomes. The coordinated
translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co …

Lung cancer is the leading cause of cancer-related deaths worldwide. Dysregulation of RNA
binding proteins (RBPs) has been found in a variety of cancers and is related to …

Deregulated mitochondrial energetics is a metabolic hallmark of cancer cells. However, the
causative mechanism of the bioenergetic deregulation is not clear. In this study, we show …

Mitochondria are prominently understood as power houses producing ATP the primary
energy currency of the cell. However, mitochondria are also known to play an important role …

Objective Polycystic ovary syndrome (PCOS) is a common endocrine disorder with high
incidence. Recently it has been implicated as a significant risk factor for endometrial cancer …