Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They
distribute in a rather immobile pool located around the microtubule‐organizing center in a …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …

Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a
variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by …