Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …

Excessive trabeculation of the cardiac left ventricular wall is a complex phenotypic substrate
associated with various physiological and pathological processes. There has been …

BACKGROUND: Less than 40% of patients with dilated cardiomyopathy (DCM) have a
pathogenic/likely pathogenic genetic variant identified. TBX20 has been linked to congenital …

Importance Genetic testing can guide management of both cardiomyopathies and
arrhythmias, but cost, yield, and uncertain results can be barriers to its use. It is unknown …

TBX20 encodes a cardiac transcription factor that is associated with atrial septal defects.
Recent studies implicate loss-of-function TBX20 variants with left ventricular non-compaction …

Inherited cardiovascular diseases are highly heterogeneous conditions with multiple genetic
loci involved. The application of advanced molecular tools, such as Next Generation …

Discrete categorization of Mendelian disease genes into dominant and recessive models
often oversimplifies their underlying genetic architecture. Cardiomyopathies (CMs) are …

Cardiomyopathies are myocardial diseases characterized by mechanical and electrical
dysfunction of the heart muscle which could lead to heart failure and life-threatening …

Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity—a
narrative review - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

In the realm of cardiovascular health, isolated left ventricular noncompaction (LVNC) stands
out for its distinct morphological features and the clinical challenges it presents, particularly …