Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

A Chamoli, AS Gosavi, UP Shirwadkar, KV Wangdale… - Oral oncology, 2021 - Elsevier
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral
cavity. The substantial risk factors for OCSCC are the consumption of tobacco products …

Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

SS Hecht, DK Hatsukami - Nature Reviews Cancer, 2022 - nature.com
Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

AW Caliri, S Tommasi, A Besaratinia - Mutation Research/Reviews in …, 2021 - Elsevier
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS–ESMO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and …

JP Machiels, CR Leemans, W Golusinski… - Annals of …, 2020 - annalsofoncology.org
Squamous cell carcinoma of the head and neck (SCCHN) arises from epithelial cells and
occurs in the oral cavity, pharynx and larynx. Nasopharyngeal carcinoma (NPC) is a disease …

Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Oral epithelial dysplasia: recognition, grading and clinical significance

E Odell, O Kujan, S Warnakulasuriya, P Sloan - Oral Diseases, 2021 - Wiley Online Library
Histopathological grading of epithelial dysplasia remains the principal laboratory method for
assessing the risk of malignant transformation in oral potentially malignant disorders …

[HTML][HTML] A snapshot of the PD-1/PD-L1 pathway

C Ghosh, G Luong, Y Sun - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Cancer cells can evade the attack from host immune systems via hijacking the regulatory
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …

Human papillomavirus as a driver of head and neck cancers

ME Sabatini, S Chiocca - British journal of cancer, 2020 - nature.com
The human papillomavirus (HPV) family includes more than 170 different types of virus that
infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical …

Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations

AL Ho, I Brana, R Haddad, J Bauman… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Mutations in the HRAS (m HRAS) proto-oncogene occur in 4%-8% of patients
with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) …