Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Marine sponges have been considered as a drug treasure house with respect to great
potential regarding their secondary metabolites. Most of the studies have been conducted …

Coastal countries have traditionally relied on the existing marine resources (eg, fishing,
food, transport, recreation, and tourism) as well as tried to support new economic endeavors …

Chimeric antigen receptor (CAR) T therapies have achieved remarkable success for treating
hematologic malignancies, yet are often accompanied by severe cytokine release syndrome …

Treatment with β-blockers is the main strategy for managing patients with heart failure and
reduced ejection fraction because of their ability to reverse the neurohumoral effects of the …

Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …

Invasion by cancer cells is a crucial step in metastasis. An oversimplified view in the
literature is that cancer cells become more deformable as they become more invasive. β …

Contrasting with the major attention that left heart failure has received, right heart failure
remains understudied both at the preclinical and clinical levels. However, right ventricle …

ß-arrestins are multifunctional proteins that modulate heptahelical 7 transmembrane
receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors …

Asthma is an allergic airway disease in which type 2-mediated inflammation has a
pathogenic role. Cardiovascular diseases (CVDs) are type 1-dominant inflammatory …