Background and Purpose Madecassoside has potent anti‐pulmonary fibrosis (PF) effects
when administered po, despite having extremely low oral bioavailability. Herein, we …

Recent studies have challenged the conventional hypothesis that inflammation is the major
player in the fibrosis cascade. Emerging evidence points to a critical role for interactions …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by the
abnormal proliferation of fibroblast and excessive deposition of extracellular matrix (ECM) …

Liver fibrosis, a precursor to cirrhosis, is the result of the deposition of extracellular matrix
(ECM) proteins and is mediated primarily by activated hepatic stellate cells (HSCs). In this …

SUMMARY 1 Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a
component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic …

Background Interferon-gamma (IFNγ) is a multifunctional cytokine with antifibrotic and
antiproliferative efficiency. We previously found that pancreatic stellate cells (PSC), the main …

Hepatic stellate cells (HSCs), following transdifferentiation to myofibroblasts plays a key role
in liver fibrosis. Therefore, attempts to attenuate this myofibroblastic phenotype would be a …

Introduction Extracellular matrix turnover, a ubiquitous dynamic biological process, can be
diverted to fibrosis. The latter can affect the intestine as a serious complication of …

Pulmonary fibrosis (PF) is a progressive fatal disorder. Bleomycin (BLM) is a widely used
chemotherapeutic agent causing PF. Numerous agents have been investigated to prevent …

Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory
fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid …