Toxicity of nanomaterials: exposure, pathways, assessment, and recent advances

P Ganguly, A Breen, SC Pillai - ACS Biomaterials Science & …, 2018 - ACS Publications
Growth in production of manufactured goods and the use of nanomaterials in consumer
products has mounted in the past few decades. Nanotoxicology or toxicity assessment of …

A review on viral biosensors to detect human pathogens

RL Caygill, GE Blair, PA Millner - Analytica chimica acta, 2010 - Elsevier
Rapid identification of viruses has important implications for medical healthcare. Current
methods for identification and quantification of particular virus are time consuming and often …

Discovery of S-217622, a noncovalent oral SARS-CoV-2 3CL protease inhibitor clinical candidate for treating COVID-19

Y Unoh, S Uehara, K Nakahara, H Nobori… - Journal of medicinal …, 2022 - ACS Publications
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens …

Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit

H Qanash, R Yahya, MM Bakri, AS Bazaid… - Scientific Reports, 2022 - nature.com
Secondary plant metabolites remain one of the key sources of therapeutic agents despite
the development of new approaches for the discovery of medicinal drugs. In the current …

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

SS Good, J Westover, KH Jung, XJ Zhou… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the
causative agent of COVID-19, is global and unprecedented. Although remdesivir has …

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

M Sasaki, K Uemura, A Sato, S Toba, T Sanaki… - PLoS …, 2021 - journals.plos.org
The spike (S) protein of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)
binds to a host cell receptor which facilitates viral entry. A polybasic motif detected at the …

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

E Keyaerts, L Vijgen, P Maes, J Neyts… - … and biophysical research …, 2004 - Elsevier
We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of
the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. Chloroquine is a …

Synthesis and antiviral activity of new pyrazole and thiazole derivatives

OI El-Sabbagh, MM Baraka, SM Ibrahim… - European journal of …, 2009 - Elsevier
New N-acetyl (5–8) and N-thiocarbamoyl (9–12) derivatives of 4, 5-dihydropyrazole were
synthesized starting from α, β-unsaturated ketones under the effect of hydrazine hydrate and …

Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus …

M Baba, R Snoeck, R Pauwels… - Antimicrobial agents and …, 1988 - Am Soc Microbiol
Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and
carrageenans) proved to be potent inhibitors for herpes simplex virus, human …

Design and synthesis of diselenobisbenzamides (DISeBAs) as nucleocapsid protein 7 (NCp7) inhibitors with anti-HIV activity

L Sancineto, A Mariotti, L Bagnoli, F Marini… - Journal of medicinal …, 2015 - ACS Publications
The interest in the synthesis of Se-containing compounds is growing with the discovery of
derivatives exhibiting various biological activities. In this manuscript, we have identified a …