1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships
Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …
resistance associated with the currently used anticancer agents create an urgent need to …
Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)
H Zhang, H Xu, CR Ashby Jr, YG Assaraf… - Medicinal research …, 2021 - Wiley Online Library
Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …
Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell
Z Yang, X Yang, Y Li, Y Cai, Y Yu, W Zhuang… - European Journal of …, 2023 - Elsevier
The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …
Cu(I)‐Catalyzed One‐Pot Synthesis of [1,2,3]Triazolo[5,1‐a] isoquinolin‐6(5H)‐one Derivatives as EGFR‐Targeting Anticancer Agents
R Samala, S Kumar Nukala… - …, 2022 - Wiley Online Library
The CuI promoted one‐pot multi‐component synthesis of new fused [1, 2, 3] triazolo [5, 1‐a]
isoquinoline derivatives (4 a–4 h, 8 a–8 f & 9 a–9 f) without isolating unsafe azides and their …
isoquinoline derivatives (4 a–4 h, 8 a–8 f & 9 a–9 f) without isolating unsafe azides and their …
1, 2, 3, 4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design
Faheem, B Karan Kumar… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Cancer is a dreadful disorder that is emerging as one of the leading causes of
mortality across the globe. The complex tumor environment, supplemented with drawbacks …
mortality across the globe. The complex tumor environment, supplemented with drawbacks …
Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives …
Q Qiu, B Liu, J Cui, Z Li, X Deng, H Qiang… - Journal of Medicinal …, 2017 - ACS Publications
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a principal obstacle for
successful cancer chemotherapy. A novel P-gp inhibitor with a quinazoline scaffold, 12k …
successful cancer chemotherapy. A novel P-gp inhibitor with a quinazoline scaffold, 12k …
Exploration of 2-((pyridin-4-ylmethyl) amino) nicotinamide derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance
Q Qiu, W Shi, Z Li, B Zhang, M Pan, J Cui… - Journal of Medicinal …, 2017 - ACS Publications
Overexpression of the ATP-binding cassette (ABC) transport proteins, like ABCB1,
commonly referred to as P-glycoprotein (P-gp), initiates active efflux of a broad spectrum of …
commonly referred to as P-glycoprotein (P-gp), initiates active efflux of a broad spectrum of …
Design, synthesis and evaluation of a novel series of inhibitors reversing P‐glycoprotein‐mediated multidrug resistance
H Ghaleb, H Li, M Kairuki, Q Qiu, X Bi… - Chemical Biology & …, 2018 - Wiley Online Library
Multidrug resistance (MDR) is still the main barrier to attaining effective results with
chemotherapy. Discovery of new chemo‐reversal agents is needed to overcome MDR. Our …
chemotherapy. Discovery of new chemo‐reversal agents is needed to overcome MDR. Our …
Secondary Metabolites from Endophytic Pestalotiopsis microspora and Their P-Glycoprotein Inhibitory Activity
YX Qian, JC Kang, YK Luo, XB Yang, J He… - Chemistry of Natural …, 2021 - Springer
Endophytic fungi are microorganisms that colonize the tissues of healthy plants without
causing apparent symptoms [1]. There is emerging interest in potential sources of novel and …
causing apparent symptoms [1]. There is emerging interest in potential sources of novel and …
Afatinib decreases P‐glycoprotein expression to promote Adriamycin toxicity of A549T cells
Y Zhang, C Wang, Y Duan, X Huo… - Journal of cellular …, 2018 - Wiley Online Library
We investigated the reversal effect of afatinib (AFT) on activity of adriamycin (ADR) in A549T
cells and clarified the related molecular mechanisms. A549T cells overexpressing P …
cells and clarified the related molecular mechanisms. A549T cells overexpressing P …