Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Candida albicans is the most implicated fungal species that grows as a commensal or
opportunistic pathogen in the human host. It is associated with many life-threatening …

Invasive fungal infections are a leading global cause of human mortality. Only three major
classes of antifungal drugs are widely used, and resistance to all three classes can arise …

Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-
line antifungal drugs for the treatment of invasive Candida infections. In clinical isolates …

Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

How cells exposed to one stress are later able to better survive other types of stress is not
well understood. In eukaryotic organisms, physiological and pathological stresses can …

Fungal pathogens pose an increasingly worrying threat to human health, food security and
ecosystem diversity. To tackle fungal infections and improve current diagnostic and …

The high morbidity and mortality of cryptococcal meningitis is due to the limited range of
therapeutic options: only three classes of antifungal drugs are available (polyenes …

A number of in vitro studies have examined the acquisition of drug resistance to the triazole
fluconazole, a first-line treatment for many Candida infections. Much less is known about …

Aneuploidy is a frequent occurrence in fungal species where it can alter gene expression
and promote adaptation to a variety of environmental cues. Multiple forms of aneuploidy …