A novel therapeutic strategy for hepatocellular carcinoma: Immunomodulatory mechanisms of selenium and/or selenoproteins on a shift towards anti-cancer

BK Wu, QH Chen, D Pan, B Chang, LX Sang - International …, 2021 - Elsevier
Selenium (Se) is an essential trace chemical element that is widely distributed worldwide.
Se exerts its immunomodulatory and nutritional activities in the human body in the form of …

Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and …

TM Al-Noshokaty, NM Mesbah, DM Abo-Elmatty… - Life Sciences, 2022 - Elsevier
Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

Development and therapeutic potential of selenazo compounds

AC Ruberte, C Sanmartin, C Aydillo… - Journal of Medicinal …, 2019 - ACS Publications
Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

Zinc and selenium co-supplementation reduces some lipid peroxidation and angiogenesis markers in a rat model of NAFLD-fed high fat diet

SN Mousavi, A Faghihi, M Motaghinejad… - Biological trace element …, 2018 - Springer
Studies have shown that non-alcoholic fatty liver disease (NAFLD) patients are more prone
to cardiovascular disease (CVD). Zinc and selenium deficiency are common in NAFLD. But …

Selenium sulfide disrupts the PLAGL2/C‐MET/STAT3‐induced resistance against mitochondrial apoptosis in hepatocellular carcinoma

T Yang, J Huo, R Xu, Q Su, W Tang… - Clinical and …, 2021 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related
deaths worldwide. Overexpression of pleomorphic adenoma gene like‐2 (PLAGL2) is …

Selenium-doped hydroxyapatite biopapers with an anti-bone tumor effect by inducing apoptosis

ZF Zhou, TW Sun, YH Qin, YJ Zhu, YY Jiang… - Biomaterials …, 2019 - pubs.rsc.org
One-dimensional hydroxyapatite (HA) particularly mimics the structure of mineralized
collagen fibrils and displays superior mechanical properties such as toughness. Herein, we …

Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

R Kaur, D Desai, S Amin, K Raza, A Bhalla… - Molecular and Cellular …, 2023 - Springer
Ulcerative colitis (UC) is an idiopathic, chronic and relapsing colonic inflammatory disease.
Despite the involvement of diverse intricate mechanisms, COX mediated inflammatory …

5-Selenocyanatouracil: A potential hypoxic radiosensitizer. Electron attachment induced formation of selenium centered radical

M Sosnowska, S Makurat… - The Journal of Physical …, 2017 - ACS Publications
The propensity of 5-selenocyanatouracil (SeCNU) to decomposition induced by attachment
of electron was scrutinized with the G3B3 composite quantum-chemical method and …

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

V Alcolea, DN Karelia, MK Pandey, D Plano… - International journal of …, 2019 - mdpi.com
The prognosis for patients with metastatic melanoma remains very poor. Constitutive signal
transducer and activator of transcription 3 (STAT3) activation has been correlated to …

[HTML][HTML] Selenium in the prevention and treatment of hepatocellular carcinoma: From biomedical investigation to clinical application

CS Cheng, N Wang, Y Feng - … of Selenium in the Environment and …, 2019 - intechopen.com
Selenium is a micronutrient that had been suggested to reduce the risk of cancer.
Hepatocellular carcinoma (HCC), a prevalent disease and one of the most lethal cancers in …