Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet,
have been linked to beneficial effects on human health associated with their metabolic and …

The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive
oxygen species, defective glucose-stimulated insulin secretion, decreased insulin …

Background and aims Caloric excess and sedentary lifestyles have led to an epidemic of
obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of …

Nanoplastics (NaPs) has reported to accumulate in the testes and cause degeneration in the
seminiferous tubules. Additionally, exogenous hydrogen sulfide (H 2 S) is proposed to …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …

NRF2 is a basic leucine zipper (bZip) transcription factor that is the master regulator of redox
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …

Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …