Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
X Chen, J Wang, P Zhao, B Dang, T Liang… - European Journal of …, 2023 - Elsevier
A series of tetrahydro-β-carboline (THβC)-based hydroxamic acids were rationally designed
and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of …
and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of …
[HTML][HTML] Pentadecanoic acid (C15: 0), an essential fatty acid, shares clinically relevant cell-based activities with leading longevity-enhancing compounds
S Venn-Watson, NJ Schork - Nutrients, 2023 - mdpi.com
Pentadecanoic acid (C15: 0) is an essential odd-chain saturated fatty acid with broad
activities relevant to protecting cardiometabolic, immune, and liver health. C15: 0 activates …
activities relevant to protecting cardiometabolic, immune, and liver health. C15: 0 activates …
Advances in dual-targeting inhibitors of HDAC6 for cancer treatment
Z Gu, S Lin, J Yu, F Jin, Q Zhang, K Xia, L Chen… - European Journal of …, 2024 - Elsevier
Abstract Histone Deacetylase 6 (HDAC6) is an essential regulator of histone acetylation
processes, exerting influence on a multitude of cellular functions such as cell motility …
processes, exerting influence on a multitude of cellular functions such as cell motility …
Multimechanism biological profiling of tetrahydro-β-carboline analogues as selective HDAC6 inhibitors for the treatment of Alzheimer's disease
T Liang, S Liu, B Dang, X Luan, Y Guo… - European journal of …, 2024 - Elsevier
With the intensive research on the pathogenesis of Alzheimer's disease (AD), inhibition of
HDAC6 appears to be a potential therapeutic approach for AD. In this paper, a series of …
HDAC6 appears to be a potential therapeutic approach for AD. In this paper, a series of …
[HTML][HTML] Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold
B Wang, Y Liu, L Zhang, Y Wang, Z Li, X Chen - Molecules, 2023 - mdpi.com
The development of selective histone deacetylase 6 inhibitors (sHDAC6is) is being
recognized as a therapeutic approach for cancers. In this paper, we designed a series of …
recognized as a therapeutic approach for cancers. In this paper, we designed a series of …
[HTML][HTML] HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing
Q Zhang, L Yan, Y Lu, X Liu, Y Yin, Q Wang, X Gu… - Respiratory …, 2024 - Springer
Background Small airway remodelling is a vital characteristic of chronic obstructive
pulmonary disease (COPD), which is mainly caused by epithelial barrier dysfunction and …
pulmonary disease (COPD), which is mainly caused by epithelial barrier dysfunction and …
[HTML][HTML] Selective HDAC6 inhibition has the potential for anti-cancer effect in renal cell carcinoma
T Anraku, M Murata, H Kuroki, A Kazama… - Journal of Personalized …, 2024 - mdpi.com
Despite significant advancements in systemic therapy for renal cell carcinoma (RCC), the
prognosis for patients with metastatic RCC remains poor, as they are often incurable …
prognosis for patients with metastatic RCC remains poor, as they are often incurable …
Ginsenoside Rh2-induced inhibition of HDAC6 promotes autophagy and apoptosis in human leukemia cells
XX Liu, S Shi, XP Shi, JY Hou, YH Hou, J Li, ZH Liu - 2024 - researchsquare.com
Abstract Background and Objective: Previous research has demonstrated that the total
saponins of Panax ginseng (TSPG) and other ginsenoside monomers can inhibit the …
saponins of Panax ginseng (TSPG) and other ginsenoside monomers can inhibit the …