Inborn errors of immunity (IEI) are multifaced diseases which can present with a variety of
phenotypes, ranging from infections to autoimmunity, lymphoproliferation, and neoplasms. In …

Abstract Juvenile Idiopathic Arthritis (JIA) is sometimes considered a diagnosis of exclusion
as the name signifies that no cause is evident for this form of arthritis. Despite this JIA has …

Introduction Autoimmune cytopenias (AICs) are a group of disorders characterized by
immune-mediated destruction of blood cells. In children, they are often secondary to immune …

The advent of next-generation sequencing (NGS) technologies has greatly expanded our
understanding of both the clinical spectra and genetic landscape of inborn errors of …

The overall disease burden of pediatric infection is high, with widely varying clinical
outcomes including death. Among the most vulnerable children, those with inborn errors of …

Severe combined immunodeficiency (SCID) is a rare and life‐threatening genetic disorder
that severely impairs the immune system's ability to defend the body against infections. Often …

Purpose Hypogammaglobulinemia in a context of lymphoma is usually considered as
secondary and prior lymphoma remains an exclusion criterion for a common variable …

Abstract Consanguineous marriages in Middle Eastern and North African (MENA) countries
are deeply-rooted tradition and highly prevalent resulting into increased prevalence of …

In recent years, gene-editing technologies have revolutionised precision medicine, and
human trials of this technology have been reported in cell-based cancer therapies and other …

Pulmonary involvement is the most common complication in patients with predominantly
antibody deficiencies (PADs). Therefore, patients require repeated imaging tests. Unlike …