Since the introduction of combined antiretroviral therapy (cART) and more effective
treatments for AIDS, there has been a dramatic shift from the weight loss and wasting that …

The cloning of the ob gene and its gene product leptin has led to the elucidation of a robust
physiologic system that maintains constancy of fat stores. Leptin is a peptide hormone …

The ob gene was cloned in 1994 using the methodology of positional cloning. Leptin, the
protein encoded by the ob gene, was identified in 1995 and shown to be a hormonal signal …

Metabolic complications relating to complex effects of viral and immune-mediated
mechanisms are now a focus of clinical care among persons living with human …

Observational studies have noted very high rates of low 25 (OH) D (vitamin D) levels in both
the general and HIV-infected populations. In HIV-infected patients, low 25 (OH) D levels are …

HIV-1/highly active antiretroviral therapy-associated lipodystrophy syndrome (HALS) is an
adipose tissue redistribution disorder characterized by subcutaneous adipose tissue …

Background Whether human immunodeficiency virus (HIV) infection is associated with the
development of nonalcoholic steatohepatitis (NASH) remains unclear. The FibroScan …

HIV-infected individuals are at increased risk for cardiovascular disease (CVD) and
lipodystrophy, but the relationship between regional adipose tissue (AT) depots and CVD …

Objective: To evaluate the effect of HIV infection on longitudinal changes in kidney function
and to identify independent predictors of kidney function changes in HIV-infected …

Identification and characterization of the molecular mechanisms contributing to the high
incidence of insulin resistance in HIV infected patients treated with combined antiretroviral …