Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part
led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …

Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …

Abstract Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-
1β, an important mediator of inflammation. The identification of the enzyme as a unique …

Cytokines and chemokines are redundant secreted proteins with growth, differentiation, and
activation functions that regulate and determine the nature of immune responses and control …

The 60 kDa tumor necrosis factor receptor (TNF&) is regarded as the major signal
transducer of TNF-induced cellular responses, whereas the signal capacity and role of the …

We addressed the impact of deleting TNF AU-rich elements (ARE) from the mouse genome
on the regulation of TNF biosynthesis and the physiology of the host. Absence of the ARE …

Cytokines and chemokines are secreted proteins involved in numerous aspects of cell
growth, differentiation, and activation. A prominent feature of these molecules is their effect …

Summary The Fas antigen (Fas) belongs to the tumor necrosis factor (TNF)/nerve growth
factor receptor family, and it mediates apoptosis. Using a soluble form of mouse Fas …