The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Calcium-activated chloride channels (CaCCs) encoded by TMEM16A,, control neuronal
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …

The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that
opens in response to an increase in intracellular Ca2+ concentration,,. The protein is …

The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional
diversity. This family contains the long sought-after Ca2+-activated chloride channels as well …

With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …

Multiple sclerosis (MS) is a chronic inflammatory, likely autoimmune disease of the central
nervous system with a combination of genetic and environmental risk factors, among which …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

Highlights•Phospholipid scramblases, responsible for the PtdSer-exposure in activated
platelets and apoptotic cells, were identified.•Distinct mechanisms mediate PtdSer-exposure …