Arachidonic acid (AA) 1 is present in vivo esterified to cell membrane glycerophospholipids.
Activation of phospholipases (eg cytosolic phospholipase A2) releases free AA from the …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

OBJECTIVE We investigated the role of cytochrome P450 of the 4A family (CYP4A), its
metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and …

Sustained cardiac hypertrophy represents one of the most common causes leading to
cardiac failure. There is emerging evidence to implicate the involvement of NF-κB in the …

Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme
into carbon monoxide, iron and bilirubin. In the recent years, HO-1 expression has been …

Small lipids such as eicosanoids exert diverse and complex functions. In addition to their
role in regulating normal kidney function, these lipids also play important roles in the …

The soluble epoxide hydrolase appears to be a promising target for the development of
antihypertensive therapies based on a previously unexplored mechanism of action. Epoxide …

Long chain fatty acids have recently emerged as critical signaling molecules in neuronal,
cardiovascular, and renal processes, yet little is presently known about the precise …