Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the
global population. Despite an array of treatment modalities, depressive disorders remain …

Fever of Unknown Origin FUO despite a high-quality workup after a reasonable amount of
time has elapsed to rule out self-limited fevers remains a challenge. The clinician must pay …

L-5-hydroxytryptophan (5-HTP) is both a drug and a natural component of some dietary
supplements. 5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is …

A prominent neurotransmitter (NT), dopamine (DA), is a chemical messenger that transmits
signals between one neuron to the next to pass on a signal to and from the central nervous …

In the last few years, there have been significant advances in migraine management and
prevention. Lasmiditan, ubrogepant, rimegepant and monoclonal antibodies (erenumab …

Purpose The emergence of novel psychoactive substances (NPS) has been being a
continuous and evolving problem for more than a decade. Every year, dozens of new …

Serotonin syndrome (SS) is an important drug-related complication of psychopharmacologic
therapy for major depression, bipolar affective disorder, obsessive-compulsive disorder …

Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

The International Journal of Molecular Sciences Special Issue “Serotonin in health and
diseases” covers several aspects of the multiple and still mysterious functions of serotonin (5 …

Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic
antidepressants gradually exhibit low therapeutic efficiency, especially for patients with …