Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma
(PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell …

Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled
as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …

Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

In this work, we demonstrate the development and first application of nanocapillary sampling
followed by analytical flow liquid chromatography–mass spectrometry for single-cell …

Rationale: The resistance of pancreatic ductal adenocarcinoma (PDAC) to immunotherapies
is caused by the immunosuppressive tumor microenvironment (TME) and dense …

Background Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second
leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to …

Gastrointestinal stromal tumors (GISTs) are the most common types of malignant
mesenchymal tumors in the gastrointestinal tract, with an estimated incidence of 1.5/100.000 …

The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …