Cell death in pancreatic cancer: from pathogenesis to therapy
Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …
Targeting PI3K/AKT/mTOR signaling pathway in pancreatic cancer: from molecular to clinical aspects
S Stanciu, F Ionita-Radu, C Stefani, D Miricescu… - International journal of …, 2022 - mdpi.com
Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …
its low incidence, it may become in the future one of the leading causes of cancer death …
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade
VE Lander, JI Belle, NL Kingston, JM Herndon… - Cancer discovery, 2022 - AACR
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma
(PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell …
(PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell …
[HTML][HTML] Liposome-based diagnostic and therapeutic applications for pancreatic cancer
Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled
as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …
as incurable. Chemotherapy continues to be the most popular treatment yet yields a very …
[HTML][HTML] GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer
C Pecoraro, B Faggion, B Balboni, D Carbone… - Drug Resistance …, 2021 - Elsevier
Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …
Single-cell lipidomics using analytical flow LC-MS characterizes the response to chemotherapy in cultured pancreatic cancer cells
KDG Saunders, J Von Gerichten, HM Lewis… - Analytical …, 2023 - ACS Publications
In this work, we demonstrate the development and first application of nanocapillary sampling
followed by analytical flow liquid chromatography–mass spectrometry for single-cell …
followed by analytical flow liquid chromatography–mass spectrometry for single-cell …
[HTML][HTML] OX40L-armed oncolytic virus boosts T-cell response and remodels tumor microenvironment for pancreatic cancer treatment
S Liu, F Li, Q Ma, M Du, H Wang, Y Zhu, L Deng… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: The resistance of pancreatic ductal adenocarcinoma (PDAC) to immunotherapies
is caused by the immunosuppressive tumor microenvironment (TME) and dense …
is caused by the immunosuppressive tumor microenvironment (TME) and dense …
[HTML][HTML] DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal …
AA Fitzgerald, S Wang, V Agarwal… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second
leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to …
leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to …
Gastrointestinal stromal tumors (GISTs): novel therapeutic strategies with immunotherapy and small molecules
C Vallilas, P Sarantis, A Kyriazoglou, E Koustas… - International Journal of …, 2021 - mdpi.com
Gastrointestinal stromal tumors (GISTs) are the most common types of malignant
mesenchymal tumors in the gastrointestinal tract, with an estimated incidence of 1.5/100.000 …
mesenchymal tumors in the gastrointestinal tract, with an estimated incidence of 1.5/100.000 …
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …