1. The development of pyruvate dehydrogenase and citrate synthase activity in rat brain
mitochondria was studied. Whereas the citrate synthase activity starts to increase at about 8 …

Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a
comprehensive discussion of enzyme interactions. It attempts to place conceptually related …

Hexokinase plays a key role in regulating cell energy metabolism. Hexokinase is mainly
particulate, bound to the mitochondrial outer membrane in brain and tumour cells. We …

Initial rate kinetic studies of soluble rat brain hexokinase indicate that the kinetic mechanism
is random Bi Bi. These studies also indicate that the ADP interaction with enzyme cannot be …

Hexokinase partitioning between the soluble and mitochondrial fractions of brain has been
observed to vary according to the energy status of the brain. Ischemia, between 0.5 and 2.5 …

It has been recognized that the rate-limiting function of pyruvate kinase M2 (PKM2) in
glycolysis plays an important role in distributing glycolytic intermediates for anabolic and …

The bioenergetic basis by which the Krebs cycle substrate pyruvate increased cardiac
contractile function over that observed with the Embden-Meyerhof substrate glucose was …

Rat brain hexokinase has been purified to homogeneity as judged by disc-gel
electrophoresis, isoelectric focusing, and analytical ultracentrifugation. More than 50% of the …

Voltage-dependent anion channels (VDACs), also known as mitochondrial porins, are the
main pathway for metabolites across the mitochondrial outer membrane and may serve as …

1. The substrate kinetic properties of cerebral hexokinases (mitochondrial and cytoplasmic)
were studied at limiting concentrations of both glucose and MgATP2−. Primary plots of the …