Stroke genetics: discovery, biology, and clinical applications
M Dichgans, SL Pulit, J Rosand - The Lancet Neurology, 2019 - thelancet.com
Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …
component. Recent gene discovery efforts have expanded the number of known single …
Heart–brain interactions in cardiac and brain diseases: why sex matters
Cardiovascular disease and brain disorders, such as depression and cognitive dysfunction,
are highly prevalent conditions and are among the leading causes limiting patient's quality …
are highly prevalent conditions and are among the leading causes limiting patient's quality …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality
Importance Recommendations for the number of steps per day may be easier to enact for
some people than the current time-and intensity-based physical activity guidelines, but the …
some people than the current time-and intensity-based physical activity guidelines, but the …
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
M Fan, D Sun, T Zhou, Y Heianza, J Lv… - European heart …, 2020 - academic.oup.com
Aims To quantify the association of combined sleep behaviours and genetic susceptibility
with the incidence of cardiovascular disease (CVD). Methods and results This study …
with the incidence of cardiovascular disease (CVD). Methods and results This study …
[HTML][HTML] Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke
Recent genome-wide association studies in stroke have enabled the generation of genomic
risk scores (GRS) but their predictive power has been modest compared to established …
risk scores (GRS) but their predictive power has been modest compared to established …
[HTML][HTML] Is cohort representativeness passé? Poststratified associations of lifestyle risk factors with mortality in the UK Biobank
Background: The UK Biobank (UKB) has been used widely to examine associations
between lifestyle risk factors and mortality outcomes. It is unknown whether the extremely …
between lifestyle risk factors and mortality outcomes. It is unknown whether the extremely …
[HTML][HTML] Vitamin D and brain health: an observational and Mendelian randomization study
Background Higher vitamin D status has been suggested to have beneficial effects on the
brain. Objectives To investigate the association between 25-hydroxyvitamin D [25 (OH) D] …
brain. Objectives To investigate the association between 25-hydroxyvitamin D [25 (OH) D] …
[HTML][HTML] Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European …
Hypertension, defined as persistently elevated systolic blood pressure (SBP)> 140 mmHg
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …
Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population
The exact etiology of dementia is still unclear, but both genetic and lifestyle factors are
thought to be key drivers of this complex disease. The recognition of familial patterns of …
thought to be key drivers of this complex disease. The recognition of familial patterns of …