An adrenal incidentaloma is now established as a common endocrine diagnosis that
requires a multidisciplinary approach for effective management. The majority of patients can …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Background: Primary aldosteronism is a nonsuppressible renin-independent aldosterone
production that causes hypertension and cardiovascular disease. Objective: To characterize …

Autonomous aldosterone overproduction represents the underlying condition of 5–10% of
patients with arterial hypertension and carries a significant burden of mortality and morbidity …

Background Mineralocorticoid receptor (MR) antagonists are the recommended medical
therapy for primary aldosteronism. Whether this recommendation effectively reduces …

Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality
rates than essential hypertension. The Japan Endocrine Society (JES) has developed an …

Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Context New approaches are needed to address the evolution of the primary aldosteronism
syndrome and to increase its recognition. Herein, we review evidence indicating that primary …

Lifelong therapy with mineralocorticoid receptor antagonists (MRAs) or surgical
adrenalectomy are the recommended treatments for primary aldosteronism (PA). Whether …