The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of
UK deaths. In the familial form of pulmonary fibrosis, causal genes have been identified in …

Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown aetiology, which makes
drug development challenging. Single administration of bleomycin directly to the lungs of …

Rationale α v integrins, key regulators of transforming growth factor-β activation and
fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial …

RNA-based medicine is receiving growing attention for its diverse roles and potential
therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe …

Pulmonary fibrosis is a devastating disease, in which fibrotic tissue progressively replaces
lung alveolar structure, resulting in chronic respiratory failure. Alveolar type II cells act as …

The activation and accumulation of lung fibroblasts resulting in aberrant deposition of
extracellular matrix components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis …

Abstract Ethnopharmacological relevance Xuanfei Baidu Decoction (XFBD), one of the
“three medicines and three prescriptions” for the clinically effective treatment of COVID-19 in …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …