Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …

The molecular machinery behind lysosome biogenesis and the maintenance of the
perinuclear aggregate of late endocytic structures is not well understood. A likely candidate …

Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic
components and organelles in a vacuole called an autophagosome that finally fuses with …

Introduction The eukaryotic cell contains membrane-bound organelles with distinct
functionality and composition. Preservation of organelle identity depends on the highly …

Rab7 is a small GTPase that controls transport to endocytic degradative compartments. Here
we report the identification of a novel 45 kDa protein that specifically binds Rab7GTP at its C …

Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R).
One feature of I/R injury is the increased presence of autophagosomes. However, to date it …

Membrane-enveloped vesicles travel among the compartments of the cytoplasm of
eukaryotic cells, delivering their specific cargo to programmed locations by membrane …

Most people infected with Mycobacterium tuberculosis contain the initial infection and
develop latent tuberculosis. This state is characterised by evidence of an immune response …

Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an
immunocompetent host. This bacterium lives within the macrophage, a cell whose function is …