Mutations in the trafficking protein particle complex C2 protein (TRAPPC2), a mammalian
ortholog of yeast Trs20p and a component of the trafficking protein particle (TRAPP) vesicle …

Generation of immune response is a crucial activity of host defense against any microbial
attack. When facultative organism Mycobacterium tuberculosis (MTB) invades its host …

Membrane fusion reactions have been considered to be primarily regulated by Rab
GTPases. In the model system of homotypic vacuole fusion in the yeast Saccharomyces …

The roles of the components of the Sec34p protein complex in intracellular membrane
trafficking, first identified in the yeast Saccharomyces cerevisiae, have yet to be …

In animal and fungal cells, cytokinesis involves an actomyosin ring that forms and contracts
at the division plane. Important new details have emerged concerning the composition …

Retrograde transport between endosomes and the trans‐Golgi network (TGN) is essential
for the recycling of membrane proteins which are involved in a range of biological …

Sorting proteins to their target membranes. The functional polarity of epithelial cells depends
upon the selective insertion of proteins and lipids into distinct plasma membrane domains …

Recent observations made in live cells expressing green fluorescent protein (GFP)-tagged
cargo markers have demonstrated the existence of large, mobile transport intermediates …

GTPase domain crystal structures of Rab5a wild type and five variants with mutations in the
phosphate-binding loop are reported here at resolutions up to 1.5 Å. Of particular interest …

Abstract Small GTPases of the Ras superfamily, which include Ras-, Rho-, Rab-, Arf-, and
Ran-family isoforms, are generally known to function as a nucleotide-dependent molecular …