Evolving therapeutic landscape of advanced hepatocellular carcinoma
C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options
In light of a global rise in obesity and type 2 diabetes, non-alcoholic fatty liver disease
(NAFLD) and non-alcoholic steatohepatitis (NASH) represent an increasingly important …
(NAFLD) and non-alcoholic steatohepatitis (NASH) represent an increasingly important …
[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Hepatocellular carcinoma (HCC) can have viral or non-viral causes,,,–. Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
[HTML][HTML] T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing
H Chi, S Zhao, J Yang, X Gao, G Peng… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC), the third most prevalent cause of cancer-
related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T …
related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T …
[HTML][HTML] Prognosis of patients with hepatocellular carcinoma treated with immunotherapy–development and validation of the CRAFITY score
B Scheiner, K Pomej, MM Kirstein, F Hucke… - Journal of …, 2022 - Elsevier
Background & Aims Immunotherapy with atezolizumab plus bevacizumab represents the
new standard of care in systemic front-line treatment of hepatocellular carcinoma (HCC) …
new standard of care in systemic front-line treatment of hepatocellular carcinoma (HCC) …
TKIs in combination with immunotherapy for hepatocellular carcinoma
B Stefanini, L Ielasi, R Chen, C Abbati… - Expert review of …, 2023 - Taylor & Francis
Introduction The treatment landscape of hepatocellular carcinoma (HCC) has significantly
changed over the last 5 years with multiple options in the frontline, second line, and beyond …
changed over the last 5 years with multiple options in the frontline, second line, and beyond …
[HTML][HTML] Tumor-associated macrophages in hepatocellular carcinoma pathogenesis, prognosis and therapy
Simple Summary Hepatocellular carcinoma (HCC) constitutes a major health burden,
accounting for> 80% of primary liver cancers globally. Inflammation has come into the …
accounting for> 80% of primary liver cancers globally. Inflammation has come into the …
[HTML][HTML] JAK/STAT signaling: molecular targets, therapeutic opportunities, and limitations of targeted inhibitions in solid malignancies
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …
myriad of cellular processes initiated by various types of ligands such as growth factors …
A Sodium Alginate‐Based Multifunctional Nanoplatform for Synergistic Chemo‐Immunotherapy of Hepatocellular Carcinoma
C Huang, T Xie, Y Liu, S Yan, F OuYang… - Advanced …, 2023 - Wiley Online Library
Efficient hepatocellular carcinoma (HCC) treatment remains a significant challenge due to
the inherent limitations of traditional strategies. The exploration of polysaccharides' natural …
the inherent limitations of traditional strategies. The exploration of polysaccharides' natural …
[HTML][HTML] Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
G Wang, M Zhang, M Cheng, X Wang, K Li, J Chen… - Cancer Letters, 2021 - Elsevier
The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …