Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-
canalicular pore system (LCS) buried within the mineralized matrix, which allows osteocytes …

Focal radiotherapy is frequently associated with skeletal damage within the radiation field.
Our previous in vitro study showed that activation of Wnt/β‐catenin pathway can overcome …

Bone has a complex hierarchical structure with structural integration from nm to cm. The
understanding of bone structure is developing rapidly due to improvements in available …

Osteocyte network architecture is closely associated with bone turnover. The cellular
mechanosensing system regulates osteocyte dendrite formation by enhancing focal …

Biocompatibility is a key issue in the development of new implant materials. In this context, a
novel class of biodegrading Mg implants exhibits promising properties with regard to …

The mammalian skeleton stores calcium and phosphate ions in bone matrix. Osteocytes in
osteocyte lacunae extend numerous dendrites into canaliculi less than a micron in diameter …

During bone remodeling, osteoblasts are known to deposit unmineralized collagenous
tissue (osteoid), which mineralizes after some time lag. Some of the osteoblasts differentiate …

Recently, increasing attention has been given to the study of osteocytes, the cells that are
thought to play an important role in bone remodeling and in the mechanisms of bone …

Chronic kidney diseases (CKD) are associated with mineral and bone diseases (MBD),
including pain, bone loss, and fractures. Bone fragility related to CKD includes the risk …

Abstract Purpose of Review Osteocytes directly modify the bone surrounding the expansive
lacunar-canalicular system (LCS) through both resorption and deposition. The existence of …