Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Engineered live bacteria could provide a new modality for treating lung infections, a major
cause of mortality worldwide. In the present study, we engineered a genome-reduced …

Chromosome organization is crucial for genome function. Here, we present a method for
visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce …

Building structural models of entire cells has been a long-standing cross-discipline
challenge for the research community, as it requires an unprecedented level of integration …

Since the nucleoid was isolated from bacteria in the 1970s, two fundamental questions
emerged and are still in the spotlight: how bacteria organize their chromosomes to fit inside …

Nucleoprotein complexes play an integral role in genome organization of both eukaryotes
and prokaryotes. Apart from their role in locally structuring and compacting DNA, several …

The regulation of higher-order chromatin structure is complex and dynamic, and a full
understanding of the suite of mechanisms governing this architecture is lacking. Here, we …