Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis.
This role has over the years transformed as knowledge regarding platelets has expanded to …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

The use of small molecules became one key cornerstone of targeted anti-cancer therapy.
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …

Simple Summary Cell death was once thought of as two distinct processes involving mainly
apoptosis or necrosis. In recent years, several different forms of cell death have gained …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a BCR-ABL
fusion gene. Imatinib has significantly improved the treatment of CML as a first-generation …

Drug resistance from BCR-ABL tyrosine kinase inhibitors (TKIs) and other
chemotherapeutics results in treatment failure and disease progression in chronic myeloid …

Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell-derived disorders
characterized by uncontrolled proliferation of differentiated myeloid cells. Two main groups …

A large proportion of patients with chronic myeloid leukemia (CML; 20%–50%) develop
resistance to imatinib in a BCR-ABL1-independent manner. Therefore, new therapeutic …

Abstract Purpose of Review Clinical factors alone do not enable us to differentiate which
patients will maintain treatment-free remission (TFR) from those who are likely to relapse …

Myeloid malignancies arise from an altered hematopoietic stem cell and mainly comprise
acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and …