Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

The discrepancies between the findings in preclinical studies, and in vivo testing and clinical
trials have resulted in the gradual decline in drug approval rates over the past decades …

Cancer treatment is rapidly evolving toward personalized medicine, which takes into
account the individual molecular and genetic variability of tumors. Sophisticated new in vitro …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

Bone primary tumors, such as osteosarcoma, are highly aggressive pediatric tumors that in
30% of the cases develop lung metastasis and are characterized by poor prognosis. Bone is …

The tumor microenvironment is crucial in the initiation and progression of cancers. The
interplay between cancer cells and the surrounding stroma shapes the tumor biology and …

Osteosarcoma (OS) is the most common primary malignant tumor of bone, which
preferentially develops lung metastasis. Although standard chemotherapy has significantly …