Bone sarcomas are rare tumour entities that arise from the mesenchyme most of which are
highly heterogeneous at the cellular, genetic and epigenetic levels. The three main types …

Targeting the supportive tumor microenvironment (TME) is an approach of high interest in
cancer drug development. However, assessing TME-targeted drug candidates presents a …

Osteosarcoma (OS) is a highly aggressive primary bone tumor. The mainstay for its
treatment is multiagent chemotherapy and surgical resection, with a 50–70% 5-year survival …

Osteosarcoma (OS) is the most common primary bone cancer in children and young adults.
This type of cancer is characterized by a high mortality rate, especially for patients with …

Porphyromonas gingivalis-induced inflammatory effects are mostly investigated in
monolayer cultured cells. The aim of this study was to develop a 3D spheroid model of …

Vascular endothelial growth factor (VEGF) is a major cytokine in tumor biology affecting
tumor survival, aggressiveness and pro-angiogenetic activities. In addition, cellular stresses …

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and
adolescents. While numerous other cancers now have promising therapeutic advances …

Cancer is a leading cause of non-communicable morbidity and mortality throughout the
world, similarly, in dogs, the most frequent cause of mortality is tumours. Some types of …

Osteosarcoma (OS) is the most common primary malignant tumor of bone that mainly affects
children and adolescents. The currently available therapies are not effective and the search …

Tissue engineering is becoming increasingly successful in providing in vitro models of
human tissues that can be used for ex vivo recapitulation of functional tissues as well as …