For more than 70% of breast cancer patients, cancer cells spread from their primary site and
metastasize to bone. Although much research has been conducted to understand the …

In order to better replicate disease and response to therapeutics 3D cell culture methods
have been increasingly developed for use in research and industry. Two key areas where …

Osteosarcoma is the most common primary bone malignancy presenting typically during
childhood and adolescence. However, few improvements of the survival outcomes for …

The load-bearing tissues such as bone, cartilage, and the osteochondral interface perform a
pivotal role in the biomechanical support and routine activities of the human body. These …

The tumour microenvironment plays a critical role in tumour progression and drug resistance
processes. Non-malignant cell players, such as fibroblasts, endothelial cells, immune cells …

We produced a three dimensional (3D) bone tumor model (BTM) to study the interactions
between healthy and tumor cells in a tumor tissue microenvironment, migration of the tumor …

Osteosarcoma is one of the most common types of primary bone cancerous tumor. The
structure of this tumor is solid, hard and irregular. Three dimensional (3D) models mimicking …

In order to enable the advent of personalized medicine, we need solid in vitro models, taking
into account the 3D microenvironment of the tumor, the human component, and the …

For more than 70% of breast cancer patients, cancer cells spread from their primary site and
metastasize to bone. Although much research has been conducted to understand the …