The discovery of natural RNA enzymes (ribozymes) prompted the pursuit of artificial DNA
enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual …

Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been
used in different areas. Compared with protein enzymes, catalytic nucleic acids are …

A novel and versatile method has been developed for modular expansion of the chemical
space of nucleic acid libraries, thus enabling the generation of nucleobase‐modified …

DNA‐based enzymes, also known as deoxyribozymes or DNAzymes, are single‐stranded
DNA molecules with catalytic activity. DNAzymes do not exist in nature but can be isolated …

Deoxyribozymes or DNAzymes are single-stranded catalytic DNA molecules that are
obtained by combinatorial in vitro selection methods. Initially conceived to function as gene …

Many different metal ions are involved in various biological functions including metallomics
and trafficking, and yet there are currently effective sensors for only a few metal ions, despite …

Molecules that covalently engage target proteins are widely used as activity-based probes
and covalent drugs. The performance of these covalent inhibitors is, however, often …

Nucleic acids play crucial roles in transferring cellular information and gene regulations.
DNA and RNA molecules have been associated with multiple human diseases and thus …

Directed evolution was first applied to diverse libraries of DNA and RNA molecules a quarter
century ago in the hope of gaining technology that would allow the creation of receptors …

Since 1994, deoxyribozymes or DNAzymes have been in vitro selected to catalyze various
types of reactions. Metal ions play a critical role in DNAzyme catalysis, and Zn2+ is a very …