The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …

Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …

Cellular metabolism dynamically regulates the epigenome via availability of the metabolite
substrates of chromatin-modifying enzymes. The impact of diet on the metabolism …

Acetylation is the most studied histone acyl modification and has been recognized as a
fundamental player in metabolic gene regulation, whereas other short-chain acyl …

Objective—IL-35 (interleukin-35) is an anti-inflammatory cytokine, which inhibits immune
responses by inducing regulatory T cells and regulatory B cells and suppressing effector T …

Axillary meristem development determines both plant architecture and crop yield; this critical
process is regulated by the PROLIFERATING CELL FACTORS (TCP) family of transcription …

Sequencing of cancer genomes has identified recurrent somatic mutations in histones,
termed oncohistones, which are frequently poorly understood. Previously we showed that …

Multiple substrate enzymes present a particular challenge when it comes to understanding
their activity in a complex system. Although a single target may be easy to model, it does not …

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate
K27M or G34R/V mutant histone H3. 3. H3. 3-G34R/V mutants are common in tumors with …

Chromatin structure and gene expression are dynamically regulated by posttranslational
modifications of histones. Recent advance in mass spectrometry has identified novel types …