Microglia: key players in retinal ageing and neurodegeneration

L Guo, S Choi, P Bikkannavar… - Frontiers in Cellular …, 2022 - frontiersin.org
Microglia are the resident immune cells of the central nervous system (CNS) and play a key
role in maintaining the normal function of the retina and brain. During early development …

Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma

S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …

Deep learning-based glaucoma detection with cropped optic cup and disc and blood vessel segmentation

MT Islam, ST Mashfu, A Faisal, SC Siam… - Ieee …, 2021 - ieeexplore.ieee.org
Glaucoma is an irreversible neurodegenerative disease, where intraocular hypertension is
developed due to the increased aqueous humor and blockage of the drainage system …

Risk of cataract and glaucoma among older persons with diabetes in India: a cross-sectional study based on LASI, Wave-1

J Khan, S Shaw - Scientific Reports, 2023 - nature.com
Abstract According to the International Diabetes Federation-2019 estimates, India is home to
77 million diabetic individuals which is projected to grow up to 147.2 million by 2045 …

[HTML][HTML] Inkjet drug printing onto contact lenses: deposition optimisation and non-destructive dose verification

TD Pollard, I Seoane-Viano, JJ Ong… - International Journal of …, 2023 - Elsevier
Inkjet printing has the potential to advance the treatment of eye diseases by printing drugs
on demand onto contact lenses for localised delivery and personalised dosing, while near …

Stress induced aging in mouse eye

Q Xu, C Rydz, VA Nguyen Huu, L Rocha… - Aging …, 2022 - Wiley Online Library
Aging, a universal process that affects all cells in an organism, is a major risk factor for a
group of neuropathies called glaucoma, where elevated intraocular pressure is one of the …

[HTML][HTML] Amyloid-beta and tau protein beyond Alzheimer's disease

M Abyadeh, V Gupta, JA Paulo… - Neural Regeneration …, 2024 - journals.lww.com
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye

A Monavarfeshani, W Yan, C Pappas… - Proceedings of the …, 2023 - National Acad Sciences
Although the visual system extends through the brain, most vision loss originates from
defects in the eye. Its central element is the neural retina, which senses light, processes …

Novel cubosome based system for ocular delivery of acetazolamide

HE Teba, IA Khalil, HM El Sorogy - Drug Delivery, 2021 - Taylor & Francis
Acetazolamide is the drug of choice for glaucoma treatment in an emergency. However, it is
not available in any topical formulation and it is available only as systemic tablets. Despite …

Nutraceuticals: a promising therapeutic approach in ophthalmology

CR Castro-Castaneda, F Altamirano-Lamarque… - Nutrients, 2022 - mdpi.com
Oxidative stress represents one of the main factors driving the pathophysiology of multiple
ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma …