Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition
with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) …

Local increase in blood flow during neural activity forms the basis for functional brain
imaging, but its mechanism remains poorly defined. Here we show that cortical astrocytes in …

Attention played a vital role in the historical development of the fi eld of psychology. Early
psychologists pondered the nature of attention and attempted to characterize its …

Early identification of dementia at the stage of mild cognitive impairment (MCI) is crucial for
timely diagnosis and intervention of Alzheimer's disease (AD). Although several pioneering …

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience
representative of the allied disciplines involved in research and patient care. After a …

Objective: To determine whether APOE genotype influences brain response and whether
nonverbal stimuli generate findings comparable with those of previous studies that used …

Functional MRI (fMRI) has had a major impact in cognitive neuroscience. fMRI now has a
small but growing role in clinical neuroimaging, with initial applications to neurosurgical …

Alzheimer disease (AD) is the most common cause of dementia in the elderly. Autopsy case
series on the sequential accumulation of neurofibrillary bundles and amyloid plaques, as …

It is now possible to reevaluate the cholinergic hypothesis of age-related cognitive
dysfunction based on a synthesis of new evidence from cholinergic stimulation studies and …