Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

Breast cancer is the most common cancer in women, responsible for over half a million
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …

Efforts were directed on the design, synthesis and evaluation of the anticancer activity of
some pyrimidine-based hydrazones against two breast cancer cell lines, MCF-7 and MDA …

The present study aims to investigate about the quantitative structure-activity relationship
(QSAR) of a series of Thiazole derivatives reported as anticancer agents (hepatocellular …

Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

The need for novel heterocyclic compounds with robust biological action is a result of the
emergence of numerous pandemics and microbial resistance. To search antibacterial and …

Z-configurated isomers are kinetically preferred molecules. Compounds with Z-configuration
are contained in many natural products, biologically active compounds and as synthons for …

In pursuit of discovering novel scaffolds that demonstrate potential inhibitory activity against
p38α MAPK and possess strong antitumor effects, we herein report the design and synthesis …

Aim: To develop an efficient and cost-effective antidiabetic agent. Methods: A simple and
convenient Hantzsch synthetic strategy was used to prepare 4-adamantyl-(2-(arylidene) …