ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …

The rise of antimicrobial resistance has created an urgent need for the development of new
methods for antibiotics delivery to patients with pulmonary infections in order to mainly …

Introduction Proper device selection is crucial for the clinical results of inhalation therapy.
However, none of the available devices fully conforms to the requirements for delivering …

Introduction: Inhalers are the most commonly used devices for lung drug delivery in asthma
and COPD. Inhaler use offers several advantages but requires the user's proper mastery …

Abstract Tiotropium/olodaterol (Stiolto® Respimat®; Spiolto® Respimat®) is an inhaled fixed-
dose combination of the long-acting muscarinic antagonist tiotropium bromide (hereafter …

Background Epithelial sodium channel (ENaC) is an important regulator of airway surface
liquid volume; ENaC is hyperactivated in cystic fibrosis (CF). ENaC inhibition is a potential …

In comparison with spontaneously breathing non-intubated subjects, intubated,
mechanically ventilated patients encounter various challenges, barriers, and opportunities in …

Tiotropium and olodaterol are mainstay treatments for chronic obstructive pulmonary
disease (COPD) and yield important clinical improvements, especially when used in fixed …

Introduction The healthcare sector contributes 5–8% of the global greenhouse gas
emissions. Global and regional organizations and governments have started to design and …

Faced with the threat of lung cancer-related deaths worldwide, small interfering RNA
(siRNA) can silence tumor related messenger RNA (mRNA) to tackle the issue of drug …