The compact and versatile oxetane motifs have gained significant attention in drug discovery
and medicinal chemistry programs. This review presents an overview of the diverse …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a
necessity to develop direct-acting antivirals that can be readily administered and are active …

Despite the prevalence of pericytes in the microvasculature of the heart, their role during
ischemia-induced remodeling remains unclear. We used multiple lineage-tracing mouse …

Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants
being observed around the globe new therapeutics, particularly direct-acting antivirals that …

Background Cross-presentation of exogenous antigens in HLA-class I molecules by
professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent …

This study evaluated the effects of Rorippa cantoniensis (Lour.) ohwi extract (RCE) on
factors associated with inflammation-related skin lesions in RAW 264.7 and HaCaT cells …

Background Systemic and local profiles have each been associated with asthma, but
parsing causal relationships between system-wide and airway-specific processes can be …

Cathepsin S (CTSS), a lysosomal protease, belongs to a family of cysteine cathepsin
proteases that promote degradation of damaged proteins in the endolysosomal pathway …

Simple Summary Oral cancer is often deadly and severely painful. Because this form of
cancer pain cannot be adequately treated with current medications including opiates, new …