[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Osteoarthritis year in review: genetics, genomics, epigenetics
Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …
[HTML][HTML] Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019
H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …
[HTML][HTML] Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu… - Cell death & …, 2022 - nature.com
Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play an
essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis …
essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis …
[HTML][HTML] Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …
significant health and social problems worldwide, its exact etiology is still unclear. With an …
Synovial joint-on-a-chip for modeling arthritis: Progress, pitfalls, and potential
Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …
afflict a substantial proportion of the global population. However, current clinical …
CircRNA-mediated ceRNA mechanism in osteoarthritis: special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation
Q Xue, Y Huang, J Chang, C Cheng, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …
The application of machine learning in early diagnosis of osteoarthritis: a narrative review
A Xuan, H Chen, T Chen, J Li, S Lu… - Therapeutic …, 2023 - journals.sagepub.com
Osteoarthritis (OA) is the commonest musculoskeletal disease worldwide, with an increasing
prevalence due to aging. It causes joint pain and disability, decreased quality of life, and a …
prevalence due to aging. It causes joint pain and disability, decreased quality of life, and a …
Emerging molecular biomarkers in osteoarthritis pathology
Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and
disability, culminating in decline in life quality. Attention has been drawn in recent years to …
disability, culminating in decline in life quality. Attention has been drawn in recent years to …
[HTML][HTML] Connection between mesenchymal stem cells therapy and osteoclasts in osteoarthritis
L Ibáñez, P Guillem-Llobat, M Marín… - International Journal of …, 2022 - mdpi.com
The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has
shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a …
shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a …