[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Osteoarthritis year in review: genetics, genomics, epigenetics

DA Young, MJ Barter, J Soul - Osteoarthritis and Cartilage, 2022 - Elsevier
Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …

[HTML][HTML] Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

[HTML][HTML] Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32

J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu… - Cell death & …, 2022 - nature.com
Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play an
essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis …

[HTML][HTML] Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

S Grässel, F Zaucke, H Madry - Journal of clinical medicine, 2021 - mdpi.com
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

Synovial joint-on-a-chip for modeling arthritis: Progress, pitfalls, and potential

ZA Li, S Sant, SK Cho, SB Goodman, BA Bunnell… - Trends in …, 2023 - cell.com
Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

CircRNA-mediated ceRNA mechanism in osteoarthritis: special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Q Xue, Y Huang, J Chang, C Cheng, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …

The application of machine learning in early diagnosis of osteoarthritis: a narrative review

A Xuan, H Chen, T Chen, J Li, S Lu… - Therapeutic …, 2023 - journals.sagepub.com
Osteoarthritis (OA) is the commonest musculoskeletal disease worldwide, with an increasing
prevalence due to aging. It causes joint pain and disability, decreased quality of life, and a …

Emerging molecular biomarkers in osteoarthritis pathology

A Sandhu, JS Rockel, S Lively… - Therapeutic Advances …, 2023 - journals.sagepub.com
Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and
disability, culminating in decline in life quality. Attention has been drawn in recent years to …

[HTML][HTML] Connection between mesenchymal stem cells therapy and osteoclasts in osteoarthritis

L Ibáñez, P Guillem-Llobat, M Marín… - International Journal of …, 2022 - mdpi.com
The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has
shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a …