Adapting to obesity with adipose tissue inflammation

SM Reilly, AR Saltiel - Nature Reviews Endocrinology, 2017 - nature.com
Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

[HTML][HTML] Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

[HTML][HTML] Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling

R Caesar, V Tremaroli, P Kovatcheva-Datchary… - Cell metabolism, 2015 - cell.com
Dietary lipids may influence the abundance of circulating inflammatory microbial factors.
Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly …

Obesity and inflammation

J Karczewski, E Śledzińska, A Baturo, I Jończyk… - European cytokine …, 2018 - Springer
The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

X Cao - Nature Reviews Immunology, 2016 - nature.com
In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …

Saturated fatty acids trigger TLR4-mediated inflammatory response

DM Rocha, AP Caldas, LL Oliveira, J Bressan… - Atherosclerosis, 2016 - Elsevier
Toll-like receptors (TLR) mediate infection-induced inflammation and sterile inflammation by
endogenous molecules. Among the TLR family, TLR4 is the best understood. However …

[HTML][HTML] Moderate dietary protein restriction alters the composition of gut microbiota and improves ileal barrier function in adult pig model

P Fan, P Liu, P Song, X Chen, X Ma - Scientific reports, 2017 - nature.com
This study was conducted to investigate impacts of dietary protein levels on gut bacterial
community and gut barrier. The intestinal microbiota of finishing pigs, fed with 16%, 13% and …

Role of adipose tissue macrophages in obesity-related disorders

S Chakarov, C Blériot, F Ginhoux - Journal of Experimental Medicine, 2022 - rupress.org
The obesity epidemic has led researchers and clinicians to reconsider the etiology of this
disease and precisely decipher its molecular mechanisms. The excessive accumulation of …