Electrospun fibers control drug delivery for tissue regeneration and cancer therapy

L Li, R Hao, J Qin, J Song, X Chen, F Rao, J Zhai… - Advanced Fiber …, 2022 - Springer
Versatile strategies have been developed to construct electrospun fiber-based drug delivery
systems for tissue regeneration and cancer therapy. We first introduce the construction of …

[HTML][HTML] 3D bioprinting: a novel avenue for manufacturing tissues and organs

B Zhang, L Gao, L Ma, Y Luo, H Yang, Z Cui - Engineering, 2019 - Elsevier
Abstract Three-dimensional (3D) bioprinting is a rapidly growing technology that has been
widely used in tissue engineering, disease studies, and drug screening. It provides the …

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

D Zhu, Z Li, K Huang, TG Caranasos, JS Rossi… - Nature …, 2021 - nature.com
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

Programming cellular alignment in engineered cardiac tissue via bioprinting anisotropic organ building blocks

JH Ahrens, SGM Uzel, M Skylar‐Scott… - Advanced …, 2022 - Wiley Online Library
The ability to replicate the 3D myocardial architecture found in human hearts is a grand
challenge. Here, the fabrication of aligned cardiac tissues via bioprinting anisotropic organ …

4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction

H Cui, C Liu, T Esworthy, Y Huang, Z Yu, X Zhou… - Science …, 2020 - science.org
There has been considerable progress in engineering cardiac scaffolds for the treatment of
myocardial infarction (MI). However, it is still challenging to replicate the structural specificity …

A minimally invasive exosome spray repairs heart after myocardial infarction

J Yao, K Huang, D Zhu, T Chen, Y Jiang, J Zhang… - ACS …, 2021 - ACS Publications
Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI
survivors will suffer from recurrent heart failure (HF), which has been recognized as a …

Human engineered heart tissue patches remuscularize the injured heart in a dose-dependent manner

E Querdel, M Reinsch, L Castro, D Köse, A Bähr… - Circulation, 2021 - Am Heart Assoc
Background: Human engineered heart tissue (EHT) transplantation represents a potential
regenerative strategy for patients with heart failure and has been successful in preclinical …

Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts

Y Tan, RC Coyle, RW Barrs, SE Silver, M Li… - Science …, 2023 - science.org
Human cardiac organoids hold remarkable potential for cardiovascular disease modeling
and human pluripotent stem cell–derived cardiomyocyte (hPSC-CM) transplantation. Here …

An intrapericardial injectable hydrogel patch for mechanical–electrical coupling with infarcted myocardium

C Yu, Z Yue, M Shi, L Jiang, S Chen, M Yao, Q Yu… - ACS …, 2022 - ACS Publications
Although hydrogel-based patches have shown promising therapeutic efficacy in myocardial
infarction (MI), synergistic mechanical, electrical, and biological cues are required to restore …

A Bi‐Layer Hydrogel Cardiac Patch Made of Recombinant Functional Proteins

X Jiang, T Feng, B An, S Ren, J Meng, K Li… - Advanced …, 2022 - Wiley Online Library
The development of minimally invasive cardiac patches, either as hemostatic dressing or
treating myocardial infarction, is of clinical significance but remains a major challenge …