Braunwald Cell-Based Therapy in Cardiac Regeneration 133 therapy rarely uses a single
administration of a drug and it would seem logical to deliver cells repeatedly in treating a …

Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While
there are many aspects to consider in the design of biomaterials, mechanical properties can …

Cardiac two-dimensional tissues were engineered using biomimetic micropatterns based on
the fibronectin-rich extracellular matrix (ECM) of the embryonic heart. The goal of this …

Cardiovascular disease is a leading cause of disability and death worldwide. Although the
survival rate of patients with heart diseases can be improved with contemporary …

Transplantation of mesenchymal stem cells (MSCs) in the setting of cardiovascular disease,
such as heart failure, cardiomyopathy and ischemic heart disease, has been associated with …

Stroke and cardiovascular episodes are still some of the most common diseases worldwide,
causing millions of deaths and costing billions of Euros to healthcare systems. The use of …

Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic
potential for the heart to self-regenerate. The introduction of novel approaches in cardiac …

Cardiovascular diseases such as myocardial infarction account for millions of worldwide
deaths annually. Cardiovascular tissues constitute a highly organized and complex three …

Background We have shown that genetic overexpression of cell cycle proteins can increase
the proliferation of transplanted cardiomyocytes derived from human induced-pluripotent …

Background The creation of a bioengineered cardiac patch (BCP) is a potential novel
strategy for myocardial repair. Nevertheless, the ideal scaffold for BCP is unknown …