Pathological angiogenesis: mechanisms and therapeutic strategies
AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …
existing ones, is an essential process for growth and development. Different mechanisms …
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment
A Emami Nejad, S Najafgholian, A Rostami… - Cancer Cell …, 2021 - Springer
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
Biodegradable polymeric nanoparticles for drug delivery to solid tumors
A Gagliardi, E Giuliano, E Venkateswararao… - Frontiers in …, 2021 - frontiersin.org
Advances in nanotechnology have favored the development of novel colloidal formulations
able to modulate the pharmacological and biopharmaceutical properties of drugs. The …
able to modulate the pharmacological and biopharmaceutical properties of drugs. The …
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Q Wu, L You, E Nepovimova, Z Heger, W Wu… - Journal of hematology & …, 2022 - Springer
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
X Jing, F Yang, C Shao, K Wei, M Xie, H Shen, Y Shu - Molecular cancer, 2019 - Springer
Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
AS Nunes, AS Barros, EC Costa… - Biotechnology and …, 2019 - Wiley Online Library
Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …
development of new anticancer agents because they are able to closely mimic the main …
The drug-resistance mechanisms of five platinum-based antitumor agents
J Zhou, Y Kang, L Chen, H Wang, J Liu… - Frontiers in …, 2020 - frontiersin.org
Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …
Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of …
L Zhou, J Jiang, Z Huang, P Jin, L Peng, M Luo… - Molecular cancer, 2022 - Springer
Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the
progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs …
progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs …
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications
G He, X Peng, S Wei, S Yang, X Li, M Huang, S Tang… - Molecular Cancer, 2022 - Springer
Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective
pressure, tumor cells show various adaptive characteristics, such as changes in the …
pressure, tumor cells show various adaptive characteristics, such as changes in the …