Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …

Unanticipated, novel hypothesis on nitric oxide (NO) radical, an inorganic, labile, gaseous
molecule, as a neurotransmitter first appeared in late 1989 and into the early 1990s, and …

Evidence is fast accumulating which indicates that Alzheimer's disease is a vascular
disorder with neurodegenerative consequences rather than a neurodegenerative disorder …

Abstract CONTINUOUS OXYGEN DELIVERY and CO 2 clearance are paramount in the
maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic …

Vascular blood flow and its distribution among different vascular beds are regulated by
changes in microvascular tone. Nitric oxide (NO) plays a key role in the local paracrine …

Cerebrovascular lesions, mainly germinal matrix hemorrhage and ischemic injury to the
periventricular white matter, are major causes of adverse neurodevelopmental outcome in …

Introduction Anemia is one of the most common medical complications to be encountered in
critically ill patients. Based on the results of clinical trials, transfusion practices across the …