[HTML][HTML] Various AAV serotypes and their applications in gene therapy: an overview

SS Issa, AA Shaimardanova, VV Solovyeva… - Cells, 2023 - mdpi.com
Despite scientific discoveries in the field of gene and cell therapy, some diseases still have
no effective treatment. Advances in genetic engineering methods have enabled the …

[HTML][HTML] Adeno-associated virus (AAV) as a vector for gene therapy

MF Naso, B Tomkowicz, WL Perry III, WR Strohl - BioDrugs, 2017 - Springer
There has been a resurgence in gene therapy efforts that is partly fueled by the identification
and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non …

[HTML][HTML] The AAV vector toolkit: poised at the clinical crossroads

A Asokan, DV Schaffer, RJ Samulski - Molecular Therapy, 2012 - cell.com
The discovery of naturally occurring adeno-associated virus (AAV) isolates in different
animal species and the generation of engineered AAV strains using molecular genetics …

[HTML][HTML] Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

J Weinmann, S Weis, J Sippel, W Tulalamba… - Nature …, 2020 - nature.com
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products
and for countless gene transfer vectors derived from natural or synthetic viral isolates that …

[HTML][HTML] The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses

LV Tse, RM Meganck, RL Graham… - Frontiers in microbiology, 2020 - frontiersin.org
Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …

[HTML][HTML] High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography

M Florea, F Nicolaou, S Pacouret, EM Zinn… - … Therapy Methods & …, 2023 - cell.com
The adeno-associated viral vector (AAV) provides a safe and efficient gene therapy platform
with several approved products that have marked therapeutic impact for patients. However …

Controlling AAV tropism in the nervous system with natural and engineered capsids

MJ Castle, HT Turunen, LH Vandenberghe… - Gene Therapy for …, 2016 - Springer
More than one hundred naturally occurring variants of adeno-associated virus (AAV) have
been identified, and this library has been further expanded by an array of techniques for …

High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction

A Westhaus, M Cabanes-Creus, A Rybicki… - Human gene …, 2020 - liebertpub.com
Adeno-associated virus (AAV) vectors are quickly becoming the vectors of choice for
therapeutic gene delivery. To date, hundreds of natural isolates and bioengineered variants …

[HTML][HTML] The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

CL Bell, LH Vandenberghe, P Bell… - The Journal of …, 2011 - Am Soc Clin Investig
Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene
delivery to many organs, but the receptor (s) mediating these tropisms have yet to be …

[HTML][HTML] Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia

Q Huang, X Deng, Z Yan, F Cheng, Y Luo, W Shen… - 2012 - journals.plos.org
Human bocavirus 1 (HBoV1) has been identified as one of the etiological agents of
wheezing in young children with acute respiratory-tract infections. In this study, we have …