[HTML][HTML] Various AAV serotypes and their applications in gene therapy: an overview
SS Issa, AA Shaimardanova, VV Solovyeva… - Cells, 2023 - mdpi.com
Despite scientific discoveries in the field of gene and cell therapy, some diseases still have
no effective treatment. Advances in genetic engineering methods have enabled the …
no effective treatment. Advances in genetic engineering methods have enabled the …
[HTML][HTML] Adeno-associated virus (AAV) as a vector for gene therapy
MF Naso, B Tomkowicz, WL Perry III, WR Strohl - BioDrugs, 2017 - Springer
There has been a resurgence in gene therapy efforts that is partly fueled by the identification
and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non …
and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non …
[HTML][HTML] The AAV vector toolkit: poised at the clinical crossroads
The discovery of naturally occurring adeno-associated virus (AAV) isolates in different
animal species and the generation of engineered AAV strains using molecular genetics …
animal species and the generation of engineered AAV strains using molecular genetics …
[HTML][HTML] Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants
J Weinmann, S Weis, J Sippel, W Tulalamba… - Nature …, 2020 - nature.com
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products
and for countless gene transfer vectors derived from natural or synthetic viral isolates that …
and for countless gene transfer vectors derived from natural or synthetic viral isolates that …
[HTML][HTML] The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses
Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
[HTML][HTML] High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography
M Florea, F Nicolaou, S Pacouret, EM Zinn… - … Therapy Methods & …, 2023 - cell.com
The adeno-associated viral vector (AAV) provides a safe and efficient gene therapy platform
with several approved products that have marked therapeutic impact for patients. However …
with several approved products that have marked therapeutic impact for patients. However …
Controlling AAV tropism in the nervous system with natural and engineered capsids
MJ Castle, HT Turunen, LH Vandenberghe… - Gene Therapy for …, 2016 - Springer
More than one hundred naturally occurring variants of adeno-associated virus (AAV) have
been identified, and this library has been further expanded by an array of techniques for …
been identified, and this library has been further expanded by an array of techniques for …
High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction
A Westhaus, M Cabanes-Creus, A Rybicki… - Human gene …, 2020 - liebertpub.com
Adeno-associated virus (AAV) vectors are quickly becoming the vectors of choice for
therapeutic gene delivery. To date, hundreds of natural isolates and bioengineered variants …
therapeutic gene delivery. To date, hundreds of natural isolates and bioengineered variants …
[HTML][HTML] The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
CL Bell, LH Vandenberghe, P Bell… - The Journal of …, 2011 - Am Soc Clin Investig
Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene
delivery to many organs, but the receptor (s) mediating these tropisms have yet to be …
delivery to many organs, but the receptor (s) mediating these tropisms have yet to be …
[HTML][HTML] Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia
Human bocavirus 1 (HBoV1) has been identified as one of the etiological agents of
wheezing in young children with acute respiratory-tract infections. In this study, we have …
wheezing in young children with acute respiratory-tract infections. In this study, we have …