Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

The data landscape in preclinical safety assessment is fundamentally changing because of
not only emerging new data types, such as human systems biology, or real-world data …

Cross-species comparison of drug responses at the organoid level could help to determine
the human relevance of findings from animal studies. To this end, we first need to evaluate …

Cell culture and invertebrate animal models reflect a significant evolution in scientific
research by providing reliable evidence on the physiopathology of diseases, screening for …

Organoids are microtissues that recapitulate the complex structural organization and
functions of tissues and organs. Nanoparticles have several specific properties that must be …

Abstract Representation of humans from diverse backgrounds in the drug development
process is key to advancing health equity, and while clinical trial design has recently made …

Plastic particles in the nanometer range–called nanoplastics–are environmental
contaminants with growing public health concern. As plastic particles are present in water …

During the last decade, organoid and organs‐on‐chip technologies have significantly
enhanced the ability to model human biology in vitro. For the pharmaceutical industry, this …

Organoids and organs-on-a-chip have emerged as powerful tools for modeling human gut
physiology and disease in vitro. Although physiologically relevant, these systems often lack …