The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-
proteasome system that recruits substrates such as the hypoxia inducible factor for …

Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

INTRODUCTION MicroRNAs (miRNAs) are short RNAs that direct widespread gene
repression in the cells of humans and other animals. Each miRNA associates with an …

Compelling evidence shows that brown and beige adipose tissue are protective against
metabolic diseases,. PR domain-containing 16 (PRDM16) is a dominant activator of the …

Metazoan organisms rely on conserved stress response pathways to alleviate adverse
conditions and preserve cellular integrity. Stress responses are particularly important in stem …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational
modification of cellular proteins involving ubiquitin. The mammalian cullin protein family …

Cullin-RING ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central
cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent …

In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-
interaction domain such as MATH recruits substrates for ubiquitination. Here, we present …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …